Research

Fellows are introduced within the curriculum to research design, statistics, and study interpretations, as well as critical review of literature to acquire skills that foster lifelong learning. Fellows participate in the recruitment and screening of patients for enrollment into clinical trials in the Division of Rheumatology.

Physicians in training, with guidance from faculty members of the Division of Rheumatology, have contributed to the writing of manuscripts and publications in peer reviewed journals and have participated in poster presentations at national conferences.

A major contributor to the enhancement of a scholarly attitude is active participation in one or more research projects, ideally followed by presentation of the work at a national meeting and publication of a paper in a peer-reviewed journal.

Selected publications:

Peer-reviewed journal articles

1. Isenberg D, Sturgess J, Allen E, Aranow C, Askanase A, Sang-Cheol B, Bernatsky S, Bruce I, Buyon J, Cervera R, Clarke A, Dooley MA, Fortin P, Ginzler E, Gladman D, Hanly J, Inanc M, Jacobsen S, Kamen D, Khamashta M, Lim S, Manzi S, Nived O, Peschken C, Petri M, Kalunian K, Rahman A, Ramsey-Goldman R, Ruiz-Irastorza G, Sanchez-Guerrero J, Steinsson K, Sturfelt G, Urowitz M, van Vollenhoven R, Wallace DJ, Zoma A, Merrill J, Gordon C. A study of flare assessment in systemic lupus erythematosus (SLE) based on paper patients. Arthritis Care Res (Hoboken). 2018 Jan;70(1):98-103.
2. Poornima IG, Shields K, Kuller LH, Manzi SM, Ramsey-Goldman R, Richardson C, Rhew E, Dunlop DD, Song J, Edmundowicz D, Kondos GT, Carr JJ, Langman CB, Price H, Chung AH, Santelices LC, Mackey RH. Associations of osteoprotegerin with coronary artery calcification among women with systemic lupus erythematosus and healthy controls. Lupus. 2018 Jan 1:961203317751060. doi: 10.1177/0961203317751060.
3. Hanly JG, Li Q, Su L, Urowitz MB, Gordon C, Bae SC, Romero-Diaz J, Sanchez-Guerrero J, Bernatsky S, Clarke AE, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Fortin P, Gladman DD, Bruce IN, Petri M, Ginzler EM, Dooley MA, Steinsson K, Ramsey-Goldman R, Zoma AA, Manzi S, Nived O, Jonsen A, Khamashta MA, Alarcón GS, Chatham W, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Ramos-Casals M, Lim SS, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askanase A, Theriault C, Farewell V. Cerebrovascular Events in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). 2018 Jan 5. doi: 10.1002/acr.23509.
4. Little J, Parker B, Lunt M, Hanly JG, Urowitz MB, Clarke AE, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Merrill JT, Buyon J, Isenberg DA, Rahman A, Ginzler EM, Petri M, Dooley MA, Fortin P, Gladman DD, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Mackay M, Alarcón GS, Manzi S, Nived O, Jönsen A, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Sam Lim S, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Sanchez-Guerrero J, Bruce IN. Glucocorticoid use and factors associated with variability in this use in the Systemic Lupus International Collaborating Clinics Inception Cohort. Rheumatology (Oxford). 2018 Jan 18. doi: 10.1093/rheumatology/kex444.
5. Bulbin D, Denio A, Berger A, Brown J, Maynard C, Sharma T, Kirchner HL, Ayoub WT. Improved Gout Outcomes in Primary Care Using a Novel Disease Management Program: A Pilot Study. Arthritis Care Res (Hoboken). 2018 Feb 13. doi: 10.1002/acr.23544.
6. Zuckerman WA, Zeevi A, Mason KL, Feingold B, Bentlejewski C, Addonizio LJ, Blume ED, Canter CE, Dipchand AI, Hsu DT, Shaddy RE, Mahle WT, Demetris AJ, Briscoe DM, Mohanakumar T, Ahearn JM, Iklé DN, Armstrong BD, Morrison Y, Diop H, Odim J, Webber SA. Study Rationale, Design and Pre-Transplant Alloantibody Status: A First Report of Clinical Trials in Organ Transplantation in Children-04 (CTOTC-04) in Pediatric Heart Transplantation. Am J Transplant. 2018 Feb 15. doi: 10.1111/ajt.14695.
7. Migliore F, Iorember FM, Gedalia A. 6-Year-Old With Severe Hypertension. Clin Pediatr (Phila). 2018 Feb;57(2):241-244.
8. Husni ME, Tang WHW, Lucke M, Chandrasekharan UM, Brennan DM, Hazen SL. HDL associated paraoxonase-1 activity correlates with systemic inflammation, disease activity and cardiovascular risk factors in psoriatic disease. Arthritis Rheumatol. 2018 Mar 23. doi: 10.1002/art.40499.
9. Merrill JT, Manzi S, Aranow C, Askenase A, Bruce I, Chakravarty E, Chong B, Costenbader K, Dall'Era M, Ginzler E, Hanrahan L, Kalunian K, Merola J, Raymond S, Rovin B, Saxena A, Werth VP. Lupus community panel proposals for optimising clinical trials: 2018. Lupus Sci Med. 2018 Mar 23;5(1):e000258. doi: 10.1136/lupus-2018-000258.
10. Piva S, Khoja S, Toledo F, Delitto A, Fitzgerald GK, Wasko MC, Goodpaster B. Neuromuscular Electrical Stimulation Compared to Volitional Exercise in Improving Muscle Function in Rheumatoid Arthritis: A Randomized Pilot Study. Arthritis Care Res (Hoboken). 2018 May 21. doi: 10.1002/acr.23602.
11. Choi MY, Clarke AE, St Pierre Y, Hanly JG, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin PR, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcón GS, Manzi S, Nived O, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Stoll T, Buyon J, Mahler M, Fritzler MJ. Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort. Arthritis Care Res (Hoboken). 2018 Jul 25. doi: 10.1002/acr.23712.
12. Faight E, Verdelis K, Ahearn JM, Shields KJ. 3D MicroCT Spatial and Temporal Characterization of Thoracic Aorta Perivascular Adipose Tissue and Plaque Volumes in the ApoE-/- Mouse Model Adipocyte. Adipocyte. 2018 Aug 9:1-10. doi: 10.1080/21623945.2018.1493900.
13. Hanley C, Shields KJ, Matthews KA, Brooks MM, Janssen I, Budoff MJ, Sekikawa A, Mulukutla S, El Khourdary SR. Associations of Cardiovascular Fat Radiodensity and Vascular Calcification in Midlife Women: The SWAN Cardiovascular Fat Ancillary Study. Atherosclerosis. 2018 Sep 8. pii: S0021-9150(18)31362-5. doi: 10.1016/j.atherosclerosis.2018.09.001.
14. Graham-Engeland JE, Song S, Mathur A, Wagstaff DA, Klein LC, Whetzel C, Ayoub WT. Emotional State Can Affect Inflammatory Responses to Pain Among Rheumatoid Arthritis Patients: Preliminary Findings. Psychol Rep. 2018 Sep 6:33294118796655. doi: 10.1177/0033294118796655.
15. Hanly JG, Li Q, Su L, Urowitz MB, Gordon C, Bae SC, Romero-Diaz J, Sanchez-Guerrero J, Bernatsky S, Clarke AE, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Petri M, Ginzler EM, Dooley MA, Steinsson K, Ramsey-Goldman R, Zoma AA, Manzi S, Nived O, Jonsen A, Khamashta MA, Alarcón GS, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Ramos-Casals M, Sam Lim S, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askanase A, Theriault C, Farewell V. Psychosis in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2018 Oct 30. doi: 10.1002/art.40764.
16. Mendel A, Bernatsky SB, Hanly JG, Urowitz MB, Clarke AE, Romero-Diaz J, Gordon C, Bae SC, Wallace DJ, Merrill JT, Buyon JP, Isenberg DA, Rahman A, Ginzler EM, Petri M, Dooley MA, Fortin PR, Gladman DD, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Mackay M, Alarcón GS, Manzi S, Nived O, Jönsen A, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim S, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Sanchez-Guerrero J, Bruce IN, Costedoat-Chalumeau N, Vinet É. Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort. Ann Rheum Dis. 2018 Dec 20. pii: annrheumdis-2018-214434. doi: 10.1136/annrheumdis-2018-214434. [Epub ahead of print]

Books, monographs, and chapters

1. Lucke M. A 50-Year-Old Woman Presents with Joint Pain (CME / ABIM MOC Monograph). Healio Rheumatology Education Lab. January 15, 2018.
2. Kimoto M, Sharma T, Manzi S. Lupus and the Cardiopulmonary System. In: Wallace DJ, Hahn BH. Dubois’ Lupus Erythematosus. Elsevier, Amsterdam. October 2018

Abstracts

1. Blundell A, Manzi S, Liu CC. A Deep Dive into the Diagnostic Utility of Eosinophil- and Basophil-C4d. (Accepted for presentation at the 2018 American Medical Women’s Association Region 5 Conference, Birmingham, AL, February 2018. First Prize, Best Original Research Poster)
2. Joshi AA, Lerman JB, Aberra TM, Dey AK, Sharma T, Castagnaro M, Patorroyo-Aponte MM, Murali S, Benza RL, Raina A. A Retrospective Study Using NIS Database 2012: Increased Clinical and Financial Burden of Heart Failure Hospitalizations in Patients with Rheumatoid Arthritis: Insights from the National Inpatient Sample (Accepted for presentation at the American College of Cardiology Annual Meeting, Orlando, FL, March 2018)
3. Blundell A, Manzi S, Liu CC. A Deep Dive into the Diagnostic Utility of Eosinophil- and Basophil-C4d. (Accepted for presentation at the 2018 American Medical Student Association Convention and Exposition, Washington, DC, March 2018)
4. Blundell A, Manzi S, Liu CC. A Deep Dive into the Diagnostic Utility of Eosinophil- and Basophil-C4d. (Accepted for presentation at the 2018 Interdisciplinary Research Symposium, San Juan Bautista School of Medicine, Caguas, PR, March 2018)
5. Blundell A, Manzi S, Liu CC. A Deep Dive into the Diagnostic Utility of Eosinophil- and Basophil-C4d. (Accepted for presentation at the American Medical Women’s Association National Meeting, Philadelphia, PA, March 2018.)
6. Blundell A, Manzi S, Liu CC. A Deep Dive into the Diagnostic Utility of Eosinophil- and Basophil-C4d. (Accepted for presentation at Latino Medical Student Association National Conference, Miami, FL, April 2018)
7. Abella K, Kim P, Sharma T. Making a Rash Decision in a Hospitalized Patient. (Accepted for presentation at the 2018 NYRIF/Clinical Congress of Rheumatology Meeting Thieves Market, Destin, FL, May 2018; Winner, Thieves Market Presentation)
8. Soeltoft K, Hallas J, Wasko MCM, Pedersen AB, Ulrichsenm SP, Ellingsen T. All-Cause Mortality and Cardiovascular Death in Hydroxychloroquine Users in Rheumatoid Arthritis Patients-A Population-Based Danish Cohort Study” (Accepted for presentation at EULAR 2018 Congress Amsterdam, Netherlands, June 2018)
9. Webster P, Abella K, Kim P, Sharma T. Making a Rash Decision in a Hospitalized Patient Accepted for presentation at PA Rheumatology Society Annual Meeting, Hershey, PA, September 2018)
10. Giles JT, Chung CP, Wasko MC, Centola M, Van Eyk J, Fert-Bober J, Kao A, Oeser AM, Stein CM, Bathon J. Exploring the Lipid Paradox Theory in Rheumatoid Arthritis: Very Low Circulating Low-Density Lipoprotein Concentration Levels Are Associated with Pro-Atherogenic Biomarkers (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)
11. Payne C, Clark M, Patel S, Allawh T, Ty-Arias MA, Davis A, Jayatilleke ‎ A.. Awareness of Fertility and Contraception Issues Among Women with Rheumatologic Diseases (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)
12. Webster P, Sharma TS. Adherence to Guideline Recommendations for Screening and Treatment of Glucocorticoid Induced Osteoporosis in Patients with Rheumatoid Arthritis on Long Term Glucocorticoid Therapy at a Tertiary Care Center (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)
13. Legge A, Kirkland S, Rockwood K, Andreou P, Bae SC, Gordon C, Romero-Díaz J, Sanchez-Guerrero J, Wallace DJ, Bernatsky S, Clarke AE, Merrill JT, Ginzler EM, Fortin PR, Gladman DD, Urowitz M, Bruce IN, Isenberg DA, Rahman A, Alarcón GS, Petri M, Khamashta MA, Dooley M, Ramsey-Goldman R, Manzi S, Steinsson K, Zoma AA, Aranow C, Mackay M, Ruiz-Irastorza G, Lim SS, Inanc M, van Vollenhoven RF, Jönsen A, Nived O, Ramos-Casals M, Kamen DL, Kalunian KC, Jacobsen S, Peschken CA, Askanase A, Hanly JG. Construction and Validation of a Frailty Index As a Novel Health Measure in Systemic Lupus Erythematosus (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)
14. Tse K, Daly RP, Hanrahan L, Anderson A, Arntsen K, Bae SC, Bruce IN, Costenbader K, Dörner T, Kao AH, Manzi S, Morand E, Raymond S, Rovin BH, Schanberg LE, Werth VP, Von Feldt J, Getz K. Global Consensus Building and Prioritization of Major Challenges in Lupus Diagnosis, Care, Treatment and Research (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)
15. Gupta A, Joshi A, Saleem O, Wasko MC, Sharma TS. Association of Hydroxychloroquine Use and Incident Atrial Fibrillation in Rheumatoid Arthritis: A Retrospective Study (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)
16. McLeod C, Olayemi G, Bhatia N, Migliore F, Quinet R. The Impact of Metformin on Disease Activity in Systemic Lupus Erythematosus (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)
17. Gupta A, Joshi A, Wasko MC, Sharma TS. Association of Hydroxychloroquine Use and Incident Atrial Fibrillation in Systemic Lupus Erythematosus: A Retrospective Study (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)
18. Hanly JG, Li Q, Su L, Urowitz M, Gordon C, Bae SC, Romero-Díaz J, Sanchez-Guerrero J, Bernatsky S, Clarke AE, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Petri M, Ginzler EM, Dooley M, Steinsson K, Ramsey-Goldman R, Zoma AA, Manzi S, Nived O, Jönsen A, Khamashta MA, Alarcón GS, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Ramos-Casals M, Lim SS, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askanase A, Theriault C, Farewell V. Psychosis in Systemic Lupus Erythematosus: Results from an International, Inception Cohort Study (Accepted for presentation at annual meeting of the American College of Rheumatology, Chicago, IL, October 2018)